Tumour budding and tumour–stroma ratio in hepatocellular carcinoma

Tumour budding and tumour–stroma ratio in hepatocellular carcinoma

Background Tumour budding and low tumour–stroma ratio (TSR) are associated with poor prognosis in some cancers, but their value in Western hepatocellular carcinoma is unclear. The prognostic value of tumour budding and TSR in hepatocellular carcinoma was examined. Methods Some 259 hepatocellular car...

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Veröffentlicht in:British journal of cancer 2020-07, Vol.123 (1), p.38-45
Hauptverfasser: Kairaluoma, Valtteri, Kemi, Niko, Pohjanen, Vesa-Matti, Saarnio, Juha, Helminen, Olli
Format: Artikel
Sprache:eng
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631/67/1504/1610/4029
692/699/1503/1607/1610/4029
Adenocarcinoma - diagnosis
Adenocarcinoma - epidemiology
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Aged
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - epidemiology
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Drug Resistance
Epidemiology
Female
Hepatocellular carcinoma
Humans
Kaplan-Meier Estimate
Liver cancer
Liver Neoplasms - diagnosis
Liver Neoplasms - epidemiology
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
Medical prognosis
Middle Aged
Molecular Medicine
Mortality
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - epidemiology
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Oncology
Prognosis
Retrospective Studies
Stroma
Stromal Cells - pathology
Tumors
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Zusammenfassung:Background Tumour budding and low tumour–stroma ratio (TSR) are associated with poor prognosis in some cancers, but their value in Western hepatocellular carcinoma is unclear. The prognostic value of tumour budding and TSR in hepatocellular carcinoma was examined. Methods Some 259 hepatocellular carcinoma patients treated in Oulu University Hospital 1983–2018 were included in this retrospective cohort study. Tumour budding and TSR were analysed from the haematoxylin- and eosin-stained original diagnostic slides, by dividing patients into bud-negative (0 bud) or bud-positive (≥1 bud) groups, and into high TSR (
ISSN:0007-0920
1532-1827
DOI:10.1038/s41416-020-0847-1