Time to intra-arrest therapeutic hypothermia in out-of-hospital cardiac arrest patients and its association with neurologic outcome: a propensity matched sub-analysis of the PRINCESS trial

Time to intra-arrest therapeutic hypothermia in out-of-hospital cardiac arrest patients and its association with neurologic outcome: a propensity matched sub-analysis of the PRINCESS trial

Purpose To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest. Methods A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal ev...

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Veröffentlicht in:Intensive care medicine 2020-07, Vol.46 (7), p.1361-1370
Hauptverfasser: Awad, Akil, Taccone, Fabio Silvio, Jonsson, Martin, Forsberg, Sune, Hollenberg, Jacob, Truhlar, Anatolij, Ringh, Mattias, Abella, Benjamin S., Becker, Lance B., Vincent, Jean-Louis, Svensson, Leif, Nordberg, Per
Format: Artikel
Sprache:eng
Schlagworte:
Ambulance services
Analysis
Anesthesiology
Cardiac arrest
Cardiac patients
Cardiopulmonary Resuscitation
Confidence intervals
Cooling
CPR
Critical Care Medicine
Emergency Medical Services
Emergency Medicine
Evaporative cooling
General & Internal Medicine
Heart
Heart attacks
Humans
Hypothermia
Hypothermia, Induced
Intensive
Intensive care
Life Sciences & Biomedicine
Medical colleges
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Odds Ratio
Original
Out-of-Hospital Cardiac Arrest - therapy
Pain Medicine
Patient outcomes
Patients
Pediatrics
Pneumology/Respiratory System
Population studies
Propensity Score
Recovering
Science & Technology
Subgroups
Treatment Outcome
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Zusammenfassung:Purpose To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest. Methods A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal evaporative intra-arrest cooling initiated by emergency medical services or cooling started after hospital arrival. Early cooling (intervention) was defined as intra-arrest cooling initiated 
ISSN:0342-4642
1432-1238
1432-1238
DOI:10.1007/s00134-020-06024-3