Comparison of uric acid reduction and renal outcomes of febuxostat vs allopurinol in patients with chronic kidney disease

Whether the clinical trial treatment effect of urate-lowering therapy (ULT) in patient with chronic kidney disease (CKD) is generalizable to real-word settings is unclear. This study aimed to compare febuxostat with allopurinol for uric acid reduction and renal protection in patients with CKD. Adult...

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Veröffentlicht in:	Scientific reports 2020-07, Vol.10 (1), p.10734, Article 10734
Hauptverfasser:	Peng, Yueh-Lung, Tain, You-Lin, Lee, Chien-Te, Yang, Yi-Hsn, Huang, Yaw-Bin, Wen, Yen-Hsia, Hsu, Chien-Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308 692/308/409 692/4022 692/700/565 Aged Aged, 80 and over Allopurinol Allopurinol - therapeutic use Cohort Studies Electronic medical records Epidermal growth factor receptors Febuxostat - therapeutic use Female Follow-Up Studies Glomerular Filtration Rate Gout Suppressants - pharmacology Humanities and Social Sciences Humans Hyperuricemia Hyperuricemia - drug therapy Hyperuricemia - epidemiology Hyperuricemia - pathology Kidney - drug effects Kidney diseases Male Middle Aged multidisciplinary Patients Prognosis Renal function Renal Insufficiency, Chronic - physiopathology Science Science (multidisciplinary) Taiwan - epidemiology Uric acid Uric Acid - metabolism
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Zusammenfassung:	Whether the clinical trial treatment effect of urate-lowering therapy (ULT) in patient with chronic kidney disease (CKD) is generalizable to real-word settings is unclear. This study aimed to compare febuxostat with allopurinol for uric acid reduction and renal protection in patients with CKD. Adult CKD patients newly treated with ULT were identified using electronic health records from 2010 to 2015 from a large healthcare delivery system in Taiwan. Patients with renal replacement therapy or undergoing ULT for
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-67026-1