TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations

During sleep, neurons in the thalamic reticular nucleus (TRN) participate in distinct types of oscillatory activity. While the reciprocal synaptic circuits between TRN and sensory relay nuclei are known to underlie the generation of sleep spindles, the mechanisms regulating slow (

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2020-06, Vol.40 (25), p.4813-4823
Hauptverfasser:	O'Malley, John J, Seibt, Frederik, Chin, Jeannie, Beierlein, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Activation Activity patterns Animals Calcium channels Calcium channels (T-type) Calcium channels (voltage-gated) Calcium influx Calcium ions Channels Circuits Depolarization Female GABAergic Neurons - physiology Glutamatergic transmission Glutamic acid receptors Glutamic acid receptors (metabotropic) Intralaminar Thalamic Nuclei - physiology Ion currents Male Mice Mice, Inbred C57BL Neural Pathways - physiology Neurogenesis Neurons Organ Culture Techniques Oscillations Receptor mechanisms Receptors Rhythms Sleep Sleep - physiology Thalamic reticular nucleus Thalamus Transient receptor potential proteins TRPM Cation Channels - metabolism
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Beschreibung
Zusammenfassung:	During sleep, neurons in the thalamic reticular nucleus (TRN) participate in distinct types of oscillatory activity. While the reciprocal synaptic circuits between TRN and sensory relay nuclei are known to underlie the generation of sleep spindles, the mechanisms regulating slow (
ISSN:	0270-6474 1529-2401
DOI:	10.1523/JNEUROSCI.0324-20.2020