An evolutionary framework for treating pediatric sarcomas
Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered.
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| Veröffentlicht in: | Cancer 2020-06, Vol.126 (11), p.2577-2587 |
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| container_end_page | 2587 |
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| container_issue | 11 |
| container_start_page | 2577 |
| container_title | Cancer |
| container_volume | 126 |
| creator | Reed, Damon R. Metts, Jonathan Pressley, Mariyah Fridley, Brooke L. Hayashi, Masanori Isakoff, Michael S. Loeb, David M. Makanji, Rikesh Roberts, Ryan D. Trucco, Matteo Wagner, Lars M. Alexandrow, Mark G. Gatenby, Robert A. Brown, Joel S. |
| description | Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered. |
| doi_str_mv | 10.1002/cncr.32777 |
| format | Article |
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When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered.</description><subject>Adaptation</subject><subject>adaptive therapy</subject><subject>Biological Evolution</subject><subject>Bone Neoplasms - therapy</subject><subject>Cancer</subject><subject>Child</subject><subject>clinical trial</subject><subject>Clinical Trials as Topic</subject><subject>evolution</subject><subject>Ewing sarcoma</subject><subject>Ewings sarcoma</subject><subject>extinction therapy</subject><subject>first strike</subject><subject>Humans</subject><subject>Models, Theoretical</subject><subject>Oncology</subject><subject>osteosarcoma</subject><subject>Osteosarcoma - therapy</subject><subject>resistance</subject><subject>Rhabdomyosarcoma</subject><subject>Rhabdomyosarcoma - therapy</subject><subject>Sarcoma - genetics</subject><subject>Sarcoma - therapy</subject><subject>Sarcoma, Ewing - therapy</subject><subject>second strike</subject><subject>Selection, Genetic</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kctKxDAUhoMoOl42PoAU3IhQPbk06WwEGbyBKIiCu5CmiUbbZkxaB9_ejKOiLlwdDufj4z_8CG1jOMAA5FB3OhxQIoRYQiMMY5EDZmQZjQCgzAtG79fQeoxPaRWkoKtojRIsOKV4hMbHXWZefTP0zncqvGU2qNbMfHjOrA9ZH4zqXfeQTU3tVB-czqIK2rcqbqIVq5potj7nBro7PbmdnOeX12cXk-PLXDNWirxmxhAMFAQwKKCsubaFKseVZbqiVlNuaypYVWPGOS8xtpgKImpBVcl1VdENdLTwToeqNbU2XR9UI6fBtSmv9MrJ35fOPcoH_yoFxUnHkmDvUxD8y2BiL1sXtWka1Rk_REmoELwsGOMJ3f2DPvkhdOk9SRhgPAZCIFH7C0oHH2Mw9jsMBjlvRM4bkR-NJHjnZ_xv9KuCBOAFMHONeftHJSdXk5uF9B2NVJZJ</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Reed, Damon R.</creator><creator>Metts, Jonathan</creator><creator>Pressley, Mariyah</creator><creator>Fridley, Brooke L.</creator><creator>Hayashi, Masanori</creator><creator>Isakoff, Michael S.</creator><creator>Loeb, David M.</creator><creator>Makanji, Rikesh</creator><creator>Roberts, Ryan D.</creator><creator>Trucco, Matteo</creator><creator>Wagner, Lars M.</creator><creator>Alexandrow, Mark G.</creator><creator>Gatenby, Robert A.</creator><creator>Brown, Joel S.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5028-744X</orcidid><orcidid>https://orcid.org/0000-0002-8238-2465</orcidid><orcidid>https://orcid.org/0000-0003-4790-9919</orcidid><orcidid>https://orcid.org/0000-0003-4661-0368</orcidid></search><sort><creationdate>20200601</creationdate><title>An evolutionary framework for treating pediatric sarcomas</title><author>Reed, Damon R. ; 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| ispartof | Cancer, 2020-06, Vol.126 (11), p.2577-2587 |
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| source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adaptation adaptive therapy Biological Evolution Bone Neoplasms - therapy Cancer Child clinical trial Clinical Trials as Topic evolution Ewing sarcoma Ewings sarcoma extinction therapy first strike Humans Models, Theoretical Oncology osteosarcoma Osteosarcoma - therapy resistance Rhabdomyosarcoma Rhabdomyosarcoma - therapy Sarcoma - genetics Sarcoma - therapy Sarcoma, Ewing - therapy second strike Selection, Genetic |
| title | An evolutionary framework for treating pediatric sarcomas |
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