An evolutionary framework for treating pediatric sarcomas

Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer 2020-06, Vol.126 (11), p.2577-2587
Hauptverfasser:	Reed, Damon R., Metts, Jonathan, Pressley, Mariyah, Fridley, Brooke L., Hayashi, Masanori, Isakoff, Michael S., Loeb, David M., Makanji, Rikesh, Roberts, Ryan D., Trucco, Matteo, Wagner, Lars M., Alexandrow, Mark G., Gatenby, Robert A., Brown, Joel S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation adaptive therapy Biological Evolution Bone Neoplasms - therapy Cancer Child clinical trial Clinical Trials as Topic evolution Ewing sarcoma Ewings sarcoma extinction therapy first strike Humans Models, Theoretical Oncology osteosarcoma Osteosarcoma - therapy resistance Rhabdomyosarcoma Rhabdomyosarcoma - therapy Sarcoma - genetics Sarcoma - therapy Sarcoma, Ewing - therapy second strike Selection, Genetic
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Beschreibung
Zusammenfassung:	Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered.
ISSN:	0008-543X 1097-0142
DOI:	10.1002/cncr.32777