Cys-LTs’ Pro-phlogistic Lung Actions Are Regulated by Cys-Maresins

Cys-LTs’ Pro-phlogistic Lung Actions Are Regulated by Cys-Maresins

Cysteinyl-leukotrienes are potent pro-phlogistic mediators in asthma. Here, metabololipidomic profiling showed that maresin conjugates in tissue regeneration (MCTRs) were abundant in lung, blocked LTD 4 -initiated human airway contraction, and accelerated murine allergic lung resolution of inflammat...

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Veröffentlicht in:Journal of allergy and clinical immunology 2019-10, Vol.145 (1), p.335-344
Hauptverfasser: Levy, Bruce D., Abdulnour, Raja-Elie E., Tavares, Alexander, Brüggemann, Thayse R., Norris, Paul C., Bai, Yan, Ai, Xingbin, Serhan, Charles N.
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Sprache:eng
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Zusammenfassung:Cysteinyl-leukotrienes are potent pro-phlogistic mediators in asthma. Here, metabololipidomic profiling showed that maresin conjugates in tissue regeneration (MCTRs) were abundant in lung, blocked LTD 4 -initiated human airway contraction, and accelerated murine allergic lung resolution of inflammation.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2019.09.028