Influenza virus glycoprotein-reactive human monoclonal antibodies

Influenza continues to be a significant public health challenge. Two glycoproteins on the surface of influenza virus, hemagglutinin and neuraminidase, play a prominent role in the process of influenza virus infection and release. Monoclonal antibodies targeting glycoproteins can effectively prevent...

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Veröffentlicht in:	Microbes and infection 2020-07, Vol.22 (6-7), p.263-271
Hauptverfasser:	Li, Yanbai, Wang, Lili, Si, Helong, Yu, Zhengsen, Tian, Shijun, Xiang, Rong, Deng, Xiaoqian, Liang, Ruiying, Jiang, Shibo, Yu, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibodies, Neutralizing - immunology Antibodies, Neutralizing - therapeutic use Epitopes Glycoproteins Hemagglutinin Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - immunology Hemagglutinin Glycoproteins, Influenza Virus - metabolism Humans Influenza A virus Influenza A virus - immunology Influenza B virus Influenza B virus - immunology Monoclonal antibodies Neuraminidase Neuraminidase - chemistry Neuraminidase - immunology Neuraminidase - metabolism Orthomyxoviridae Infections - therapy Orthomyxoviridae Infections - virology
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Beschreibung
Zusammenfassung:	Influenza continues to be a significant public health challenge. Two glycoproteins on the surface of influenza virus, hemagglutinin and neuraminidase, play a prominent role in the process of influenza virus infection and release. Monoclonal antibodies targeting glycoproteins can effectively prevent the spread of the virus. In this review, we summarized currently reported human monoclonal antibodies targeting glycoproteins of influenza A and B viruses.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2020.06.003