Clonal haematopoiesis and COVID‐19: A possible deadly liaison

We provide evidence for a linear correlation between the frequency of clonal haematopoiesis and COVID‐19 mortality rate. We discuss the mechanistic explanations for this association mediated by a pathological inflammatory response. Our hypothesis can be tested in COVID‐19‐infected patients and event...

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Veröffentlicht in:	International journal of immunogenetics 2020-08, Vol.47 (4), p.329-331
Hauptverfasser:	Shivarov, Velizar, Ivanova, Milena
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged, 80 and over Aging - immunology ARDS Betacoronavirus - immunology clonal haematopoiesis Clonal Selection, Antigen-Mediated - immunology Coronavirus Infections - immunology Coronavirus Infections - mortality Coronavirus Infections - pathology COVID-19 Disease Association Studies Hematopoiesis - immunology Humans Inflammation Pandemics Pneumonia, Viral - immunology Pneumonia, Viral - mortality Pneumonia, Viral - pathology SARS-CoV-2 Short Communication
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Beschreibung
Zusammenfassung:	We provide evidence for a linear correlation between the frequency of clonal haematopoiesis and COVID‐19 mortality rate. We discuss the mechanistic explanations for this association mediated by a pathological inflammatory response. Our hypothesis can be tested in COVID‐19‐infected patients and eventually lead to new approaches to risk stratification and therapy.
ISSN:	1744-3121 1744-313X
DOI:	10.1111/iji.12503