Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients?

•COVID-19 patients may have persistently positive RT-PCRs for as many as 9 weeks.•Some are being required to continue in isolation until they have negative results.•SARS-CoV-2 qualitative RT-PCR does not distinguish infectious from noninfectious.•Quantitative RT-PCRs and immunoassays are better mark...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of infection 2020-09, Vol.81 (3), p.452-482
Hauptverfasser:	Krupp, Karl, Madhivanan, Purnima, Perez-Velez, Carlos M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Betacoronavirus - isolation & purification Clinical Laboratory Techniques Coronavirus disease 2019 (COVID-19) Coronavirus Infections - blood Coronavirus Infections - diagnosis Coronavirus Infections - virology COVID-19 COVID-19 Testing Humans Infectivity Pandemics Patient Isolation Patient Isolation - psychology Pneumonia, Viral - blood Pneumonia, Viral - virology Polymerase chain reaction (PCR) Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Social Isolation Socioeconomic Factors Socioeconomic Impact Virus Shedding
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	•COVID-19 patients may have persistently positive RT-PCRs for as many as 9 weeks.•Some are being required to continue in isolation until they have negative results.•SARS-CoV-2 qualitative RT-PCR does not distinguish infectious from noninfectious.•Quantitative RT-PCRs and immunoassays are better markers of infectivity period.•Social isolation can have economic, physical, psychological, and social effects.
ISSN:	0163-4453 1532-2742
DOI:	10.1016/j.jinf.2020.06.030