An Animal Model of Inhaled Vitamin E Acetate and EVALI-like Lung Injury

In this study, investigators developed a mouse model of e-cigarette, or vaping, product use–associated lung injury. They showed that in these mice, vitamin E acetate induced lung injury that had many similarities to what has been seen in human cases.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-03, Vol.382 (12), p.1175-1177
Hauptverfasser:	Bhat, Tariq A, Kalathil, Suresh G, Bogner, Paul N, Blount, Benjamin C, Goniewicz, Maciej L, Thanavala, Yasmin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Acetic acid Aerosols Animal models Animals Bronchoalveolar Lavage Fluid - chemistry Disease control Disease Models, Animal Drug dosages Electronic cigarettes Electronic Nicotine Delivery Systems Leukocyte Common Antigens - analysis Leukocytes Lung - chemistry Lung - drug effects Lung - pathology Lung Injury - etiology Lungs Mice Vaping - adverse effects Vitamin E Vitamin E - adverse effects Vitamin E - analysis
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Beschreibung
Zusammenfassung:	In this study, investigators developed a mouse model of e-cigarette, or vaping, product use–associated lung injury. They showed that in these mice, vitamin E acetate induced lung injury that had many similarities to what has been seen in human cases.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMc2000231