Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study

Purpose Obesity and insulin resistance have been associated with poor prognosis in breast cancer (BC). The present prospective study aimed to investigate the impact of metabolic syndrome (MetS) and its components on early BC (eBC) patients’ outcome. Methods MetS was defined by the presence of 3 to 5...

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Veröffentlicht in:	Breast cancer research and treatment 2020-07, Vol.182 (2), p.401-409
Hauptverfasser:	Buono, Giuseppe, Crispo, Anna, Giuliano, Mario, De Angelis, Carmine, Schettini, Francesco, Forestieri, Valeria, Lauria, Rossella, De Laurentiis, Michelino, De Placido, Pietro, Rea, Carmen Giusy, Pacilio, Carmen, Esposito, Emanuela, Grimaldi, Maria, Nocerino, Flavia, Porciello, Giuseppe, Giudice, Aldo, Amore, Alfonso, Minopoli, Anita, Botti, Gerardo, De Placido, Sabino, Trivedi, Meghana V., Arpino, Grazia
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Blood pressure Breast cancer Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Cancer research Clinical Trial Comorbidity Diagnosis Disease-Free Survival Female Follow-Up Studies Health risk assessment Humans Insulin Medical prognosis Medicine Medicine & Public Health Metabolic syndrome Metabolic Syndrome - diagnosis Metabolic Syndrome - epidemiology Middle Aged Multivariate analysis Observational studies Oncology Population studies Post-menopause Prospective Studies Risk Assessment Risk Factors Serum levels Survival Triglycerides Waist Circumference
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Zusammenfassung:	Purpose Obesity and insulin resistance have been associated with poor prognosis in breast cancer (BC). The present prospective study aimed to investigate the impact of metabolic syndrome (MetS) and its components on early BC (eBC) patients’ outcome. Methods MetS was defined by the presence of 3 to 5 of the following components: waist circumference > 88 cm, blood pressure ≥ 130/≥ 85 mmHg, serum levels of triglycerides ≥ 150 mg/dL, high density lipoprotein
ISSN:	0167-6806 1573-7217 1573-7217
DOI:	10.1007/s10549-020-05701-7