Risk factors for death in 1859 subjects with COVID-19

We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated wit...

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Veröffentlicht in:	Leukemia 2020-08, Vol.34 (8), p.2173-2183
Hauptverfasser:	Chen, Lei, Yu, Jianming, He, Wenjuan, Chen, Li, Yuan, Guolin, Dong, Fang, Chen, Wenlan, Cao, Yulin, Yang, Jingyan, Cai, Liling, Wu, Di, Ran, Qijie, Li, Lei, Liu, Qiaomei, Ren, Wenxiang, Gao, Fei, Wang, Hongxiang, Chen, Zhichao, Gale, Robert Peter, Li, Qiubai, Hu, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	692/499 692/699/255 Adult Aged Aged, 80 and over Betacoronavirus - isolation & purification Biomarkers - blood Cancer Research China Confidence intervals Coronavirus Infections - blood Coronavirus Infections - mortality Coronavirus Infections - pathology Coronaviruses COVID-19 Creatinine Critical Care Medicine Death Dimers Female Follow-Up Studies Hematology Humans Intensive Internal Medicine Lymphocytes Lymphocytes - pathology Male Medicine Medicine & Public Health Middle Aged Mortality Mortality - trends Neutrophils - pathology Oncology Pandemics Platelets Pneumonia, Viral - blood Pneumonia, Viral - mortality Pneumonia, Viral - pathology Prognosis Regression analysis Risk analysis Risk Factors ROC Curve SARS-CoV-2 Severity of Illness Index Statistical analysis Survival Rate Thromboplastin
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Beschreibung
Zusammenfassung:	We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated with several admission covariates: (1) older age (HR = 1.04; 95% Confidence Interval [CI], 1.03, 1.06 per year increase; P
ISSN:	0887-6924 1476-5551
DOI:	10.1038/s41375-020-0911-0