Immune checkpoint blockade: releasing the breaks or a protective barrier to COVID-19 severe acute respiratory syndrome?

Summary The rapid emergence of COVID-19 has sent shockwaves through healthcare systems globally, with cancer patients at increased risk. The interplay of the virus and host immune system has been implicated in the development of ARDS. Immunotherapy agents have the potential to adversely potentiate t...

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Veröffentlicht in:	British journal of cancer 2020-09, Vol.123 (5), p.691-693
Hauptverfasser:	Pickles, Oliver J., Lee, Lennard Y. W., Starkey, Thomas, Freeman-Mills, Luke, Olsson-Brown, Anna, Cheng, Vinton, Hughes, Daniel J., Lee, Alvin, Purshouse, Karin, Middleton, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4028/67 692/4028/67/1059/2325 B7-H1 Antigen - antagonists & inhibitors Betacoronavirus - immunology Biomedical and Life Sciences Biomedicine Cancer Research Clinical Decision-Making Comment Coronavirus Infections - epidemiology Coronavirus Infections - immunology Coronavirus Infections - virology Coronaviruses COVID-19 CTLA-4 Antigen - antagonists & inhibitors Drug Resistance Epidemiology Humans Immune checkpoint Immune system Immunosuppression Therapy - adverse effects Immunosuppression Therapy - methods Immunosuppressive Agents - adverse effects Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Immunotherapy Incidence Interleukin-6 - antagonists & inhibitors Interleukin-6 - blood Molecular Medicine Neoplasms - therapy Oncologists - psychology Oncology Pandemics Pneumonia, Viral - epidemiology Pneumonia, Viral - immunology Pneumonia, Viral - virology Respiratory Distress Syndrome - immunology SARS-CoV-2 Severe acute respiratory syndrome Treatment Outcome
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Beschreibung
Zusammenfassung:	Summary The rapid emergence of COVID-19 has sent shockwaves through healthcare systems globally, with cancer patients at increased risk. The interplay of the virus and host immune system has been implicated in the development of ARDS. Immunotherapy agents have the potential to adversely potentiate this phenomenon, requiring careful real-world observation.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/s41416-020-0930-7