Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease

Dopaminergic progenitor cells that were derived from a patient’s induced pluripotent stem cells were implanted bilaterally in the putamen. Clinical and PET studies suggested survival of the cells and clinical stability over a period of 24 months, without dyskinesias.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-05, Vol.382 (20), p.1926-1932
Hauptverfasser:	Schweitzer, Jeffrey S, Song, Bin, Herrington, Todd M, Park, Tae-Yoon, Lee, Nayeon, Ko, Sanghyeok, Jeon, Jeha, Cha, Young, Kim, Kyungsang, Li, Quanzheng, Henchcliffe, Claire, Kaplitt, Michael, Neff, Carolyn, Rapalino, Otto, Seo, Hyemyung, Lee, In-Hee, Kim, Jisun, Kim, Taewoo, Petsko, Gregory A, Ritz, Jerome, Cohen, Bruce M, Kong, Sek-Won, Leblanc, Pierre, Carter, Bob S, Kim, Kwang-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Autografts Basal Ganglia - diagnostic imaging Basal Ganglia - metabolism Cell adhesion & migration Cell Differentiation Dihydroxyphenylalanine Disease Models, Animal Dopamine Dopamine receptors Dopaminergic Neurons - cytology Dopaminergic Neurons - metabolism Dopaminergic Neurons - transplantation Drug dosages FDA approval Fibroblasts Follow-Up Studies Hemispheric laterality Humans Immunogenicity Immunosuppression Induced Pluripotent Stem Cells - immunology Induced Pluripotent Stem Cells - transplantation Inhibitory postsynaptic potentials Leukocytes (mononuclear) Magnetic resonance imaging Male Mesencephalon Mice Mice, SCID Movement disorders Mutation Neurodegenerative diseases Neurons Parkinson Disease - diagnostic imaging Parkinson Disease - therapy Parkinson's disease Pars Compacta - cytology Patients Peripheral blood Pluripotency Positron emission tomography Progenitor cells Putamen Putamen - diagnostic imaging Radioisotopes Stem cell transplantation Stem cells Substantia nigra Surgery Tomography, X-Ray Computed Transplantation, Autologous Transplantation, Homologous Transplants & implants
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Beschreibung
Zusammenfassung:	Dopaminergic progenitor cells that were derived from a patient’s induced pluripotent stem cells were implanted bilaterally in the putamen. Clinical and PET studies suggested survival of the cells and clinical stability over a period of 24 months, without dyskinesias.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1915872