Prognostic value of microRNAs in pancreatic cancer: a meta-analysis

The prognostic impact of microRNA (miRNA) expression levels in pancreatic cancer (PC) has been estimated for years, but the outcomes are controversial and heterogeneous. Therefore, we comprehensively reviewed the evidence collected on miRNA expression in PC to determine this effect. PC patients with...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2020-05, Vol.12 (10), p.9380-9404
Hauptverfasser:	Zhao, Fei, Wei, Chao, Cui, Meng-Ying, Xia, Qiang-Qiang, Wang, Shuai-Bin, Zhang, Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - blood Humans MicroRNAs - blood Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Prognosis Research Paper Sensitivity and Specificity
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Zusammenfassung:	The prognostic impact of microRNA (miRNA) expression levels in pancreatic cancer (PC) has been estimated for years, but the outcomes are controversial and heterogeneous. Therefore, we comprehensively reviewed the evidence collected on miRNA expression in PC to determine this effect. PC patients with high miR-21 (HR=2.61, 95%CI=1.68-4.04), miR-451a (HR=2.23, 95%CI=1.23-4.04) or miR-1290 (HR=1.43, 95%CI=1.04-1.95) levels in blood had significantly poorer OS (P
ISSN:	1945-4589 1945-4589
DOI:	10.18632/aging.103214