Primary hepatic neuroendocrine tumor: A case report and literature review

•Primary hepatic neuroendocrine tumors are rare neoplasms, with less than 200 cases reported.•The clinical presentation of PHNETs is non-specific and its radiologic features are intensely diversified.•Surgical resection with clear margins is the mainstay treatment for PHNETs, with very positive results.•For unresectable tumors, liver transplantation and transcatheter arterial chemoembolization are the main options. Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare, having less than 200 cases reported in the literature. A 51-year-old woman presenting with mild intensity sharp pain in the upper abdomen that started 4 years ago. Preoperative Magnetic Resonance Imaging (MRI) suggested hepatocellular adenoma. Surgical exploration found a tumor occupying the whole segment IV of the liver, therefore a left hepatectomy was performed. Pathology and immunohistochemistry indicated to be a low-grade neuroendocrine tumor of the liver. The patient is enjoying a good quality of life, free of disease, presenting no signs of recurrence nor metastases 12 months after the procedure. The clinical presentation of PHNETs is non-specific and its radiologic features are intensely diversified, frequently leading to misdiagnosis of other hepatic neoplasms.