The Effects of Exercise Training on the Brain-Derived Neurotrophic Factor (BDNF) in the Patients with Type 2 Diabetes: A Systematic Review of the Randomized Controlled Trials

Purpose Glucose dysregulation is one of the distinctive features of type 2 diabetes that is associated with an increased risk of cognitive impairment and dementia. The low concentrations of brain-derived neurotrophic factor (BDNF) are reported in people with insulin resistance, metabolic syndrome, and type 2 diabetes. BDNF can be increased by an adjustment in lifestyle including caloric restriction and exercise training. Studies have reported controversial findings about physical activity and its association with BDNF, but there is no comprehensive conclusions on this issue. The aim of this study was to systematically review the effects of exercise training on BDNF levels in patients with type 2 diabetes. Methods The electronic databases of Embase, Pedro, PubMed, Medline, Cochrane Library, as well as the Google Scholar search engine were used to obtain the related data about the role of exercise training on BDNF levels in patients with type 2 diabetes. The search period was set from inception to August 2019. Keywords of “exercise”, “training”, “physical activity”, “brain-derived neurotrophic factor”, “type 2 diabetes”, and “randomized clinical trials”, were used in persian and English. The PEDro scale was used to evaluate the quality of the included articles. Results. Finally, 11 articles (four human and seven animal articles) with medium to high quality were included in the study which 5 articles reported elevation (one human and four animal articles), 4 articles reported a reduction (one human and three animal articles), and 2 articles reported no changes (both of them in human articles) in BDNF level following the exercise training. Conclusion Decreased energy intake and increased energy expenditure through exercise training may modulate BDNF levels in patients with type 2 diabetes.