Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase

Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and stereospecificities (i.e., 100 ± 5% of the 12­(...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 2019-02, Vol.58 (6), p.848-857
Hauptverfasser:	Aleem, Ansari Mukhtar, Tsai, Wan-Chen, Tena, Jennyfer, Alvarez, Gabriella, Deschamps, Joshua, Kalyanaraman, Chakrapani, Jacobson, Matthew P, Holman, Theodore
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!