Comparative assessment of faecal microbial composition and metabonome of swine, farmers and human control

The gastrointestinal tract of humans and swine consist of a wide range of bacteria which interact with hosts metabolism. Due to the differences in co-evolution and co-adaptation, a large fraction of the gut microbiome is host-specific. In this study, we evaluated the effect of close human-animal int...

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Veröffentlicht in:	Scientific reports 2020-06, Vol.10 (1), p.8997, Article 8997
Hauptverfasser:	Tan, Shiang Chiet, Chong, Chun Wie, Yap, Ivan Kok Seng, Thong, Kwai Lin, Teh, Cindy Shuan Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326 631/326/2565 631/326/41 Animal human relations Animals Bacteria Butyrates - analysis Case-Control Studies Coadaptation Digestive system Farmers Feces - microbiology Functional plasticity Gastrointestinal Microbiome - genetics Gastrointestinal Microbiome - physiology Gastrointestinal tract Humanities and Social Sciences Intestinal microflora Malaysia Metabolites Metabolome - physiology Metagenome - genetics Methylamines - analysis Microbiomes Microbiota multidisciplinary Multidisciplinary Sciences Occupational exposure Polymorphism, Restriction Fragment Length Relative abundance RNA, Ribosomal, 16S Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Sus scrofa - microbiology Swine Trimethylamine
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Zusammenfassung:	The gastrointestinal tract of humans and swine consist of a wide range of bacteria which interact with hosts metabolism. Due to the differences in co-evolution and co-adaptation, a large fraction of the gut microbiome is host-specific. In this study, we evaluated the effect of close human-animal interaction to the faecal metagenome and metabonome of swine, farmer and human control. Three distinct clusters were observed based on T-RFLP-derived faecal microbial composition. However, 16S-inferred faecal microbiota and metabolic profiles showed that only human control was significantly different from the swine (P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-65891-4