On the Alert for Cytokine Storm: Immunopathology in COVID‐19

Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapol...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2020-07, Vol.72 (7), p.1059-1063
Hauptverfasser:	Henderson, Lauren A., Canna, Scott W., Schulert, Grant S., Volpi, Stefano, Lee, Pui Y., Kernan, Kate F., Caricchio, Roberto, Mahmud, Shawn, Hazen, Melissa M., Halyabar, Olha, Hoyt, Kacie J., Han, Joseph, Grom, Alexei A., Gattorno, Marco, Ravelli, Angelo, Benedetti, Fabrizio, Behrens, Edward M., Cron, Randy Q., Nigrovic, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - therapeutic use Betacoronavirus Biomarkers Coronavirus Infections - complications Coronavirus Infections - immunology Coronavirus Infections - therapy COVID-19 Cytokine Release Syndrome - diagnosis Cytokine Release Syndrome - drug therapy Cytokine Release Syndrome - virology Cytokine storm Cytokines Early Medical Intervention Humans Notes From the Field Pandemics Pneumonia, Viral - complications Pneumonia, Viral - immunology Pneumonia, Viral - therapy SARS-CoV-2
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Zusammenfassung:	Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID‐19.
ISSN:	2326-5191 2326-5205
DOI:	10.1002/art.41285