Characterizing the Acute Phase Response in Healthy Patients Following Total Joint Arthroplasty: Predictable and Consistent

Abstract Background During surgery, trauma to musculoskeletal tissue induces a systemic reaction known as the acute phase response (APR). When excessive or prolonged, the APR has been implicated as an underlying cause of surgical complications. The purpose of this study was to determine the typical...

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Veröffentlicht in:	The Journal of arthroplasty 2017-01, Vol.32 (1), p.309-314
Hauptverfasser:	Oelsner, William K., BS, Engstrom, Stephen M., MD, Benvenuti, Michael A., BS, An, Thomas J., AB, Jacobson, Richard A., MD, Polkowski, Gregory G., MD MSc, Schoenecker, Jonathan G., MD PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	acute phase response Acute-Phase Reaction - diagnosis Acute-Phase Reaction - etiology Acute-Phase Reaction - physiopathology Aged Aged, 80 and over Arthroplasty, Replacement, Hip - adverse effects Arthroplasty, Replacement, Knee - adverse effects C-reactive protein C-Reactive Protein - analysis Female fibrinogen Fibrinogen - analysis healthy Humans Male Middle Aged Orthopedics Osteoarthritis, Hip - physiopathology Osteoarthritis, Hip - surgery Postoperative Period Retrospective Studies total joint arthroplasty
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Zusammenfassung:	Abstract Background During surgery, trauma to musculoskeletal tissue induces a systemic reaction known as the acute phase response (APR). When excessive or prolonged, the APR has been implicated as an underlying cause of surgical complications. The purpose of this study was to determine the typical APR following TJA in a healthy population defined by the Charlson Comorbidity Index. Methods This retrospective study identified 180 healthy patients (Charlson Comorbidity Index
ISSN:	0883-5403 1532-8406
DOI:	10.1016/j.arth.2016.06.027