Bilateral retinal detachment after chimeric antigen receptor T-cell therapy

•CAR T-cell targeting of leukemic infiltrates in the optic nerve and retina caused retinal detachment as a presentation of pseudoprogression.•Treatment of this intraocular inflammation with intravitreal triamcinolone and orbital radiation led to marked improvement in visual acuity. [Display omitted]...

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Veröffentlicht in:	Blood advances 2020-05, Vol.4 (10), p.2158-2162
Hauptverfasser:	Denton, Christopher C., Gange, William S., Abdel-Azim, Hisham, Jodele, Sonata, Kapoor, Neena, Oberley, Matthew J., Wong, Kenneth, Kim, Jonathan, Vercio, Abby, Moghaddampour, Parisah, Chalam, K.V., Sierpina, David, Gardner, Rebecca A., Pulsipher, Michael A., Jensen, Michael C., Nagiel, Aaron
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell- and Tissue-Based Therapy Exceptional Case Report Humans Immunotherapy, Adoptive Receptors, Chimeric Antigen - genetics Retinal Detachment - etiology Retinal Detachment - therapy
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Beschreibung
Zusammenfassung:	•CAR T-cell targeting of leukemic infiltrates in the optic nerve and retina caused retinal detachment as a presentation of pseudoprogression.•Treatment of this intraocular inflammation with intravitreal triamcinolone and orbital radiation led to marked improvement in visual acuity. [Display omitted]
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2020001450