Interfacial bioconjugation on emulsion droplet for biosensors

[Display omitted] Interfacial bioconjugation methods are developed for intact liquid emulsion droplets. Complex emulsion droplets having internal hydrocarbon and fluorocarbon immiscible structured phases maintain a dynamic interface for controlled interfacial reactivity. The internal morphological c...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2018-10, Vol.26 (19), p.5307-5313
Hauptverfasser: Zhang, Qifan, Scigliano, Anita, Biver, Tarita, Pucci, Andrea, Swager, Timothy M.
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Sprache:eng
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Zusammenfassung:[Display omitted] Interfacial bioconjugation methods are developed for intact liquid emulsion droplets. Complex emulsion droplets having internal hydrocarbon and fluorocarbon immiscible structured phases maintain a dynamic interface for controlled interfacial reactivity. The internal morphological change after binding to biomolecules is readily visualized and detected by light transmission, which provides a platform for the formation of inexpensive and portable bio-sensing assays for enzymes, antibodies, nucleic acids and carbohydrates.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2018.04.020