Elevated cardiac biomarkers are associated with increased mortality for inpatients with COVID-19: A retrospective case-control study

Compared with survivors, non-survivors had statistically higher levels of creatinine kinase-myocardial band (CK-MB), CK, lactate dehydrogenase, myoglobin, and Troponin I. For every increase of 112 in serum myoglobin levels, mortality increased by 3.15% in generalized estimation equation analysis. [...]we suggest that: firstly, in addition to the protection of the lungs first, the time window of therapeutic interventions about cardiac injury should be as early as possible for severe patients; secondly, inflammatory factor release should be blocked early, especially in elderly (>65 years) patients with cardiovascular diseases. [...]our study provides important documentation that in this single-center, an elevated serum concentration of myoglobin (≥306.5 μg/L) is associated with an increased risk of hospitalization mortality in non-survivor with NCIP, independent of elevation in CK-MB and Troponin I levels.Declaration of competing interest No conflict of interest exits in the submission of this manuscript.