Phytochemical Analysis and Antidepressant Activity of Ixora coccinea Extracts in Experimental Models of Depression in Mice

Phytochemical Analysis and Antidepressant Activity of Ixora coccinea Extracts in Experimental Models of Depression in Mice

The present study aims to assess the antidepressant activity of extracts in mice and phytochemical analysis of the active extract by GC-MS. After oral administration of extracts, tail suspension test (TST), force swim tests (FST), and open field tests (OFT) were performed to assess the antidepressan...

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Veröffentlicht in:The Turkish Journal of Pharmaceutical Sciences 2018-08, Vol.15 (2), p.130-135
Hauptverfasser: Surana, Ajaykumar Rikhabchand, Wagh, Rajendra Dayaram
Format: Artikel
Sprache:eng
Schlagworte:
Antidepressants
Drug dosages
Eczacılık
Laboratory animals
Mental depression
Original
Pharmacy
Phytochemicals
Sağlık Hizmetleri
Swimming
Tıp
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Zusammenfassung:The present study aims to assess the antidepressant activity of extracts in mice and phytochemical analysis of the active extract by GC-MS. After oral administration of extracts, tail suspension test (TST), force swim tests (FST), and open field tests (OFT) were performed to assess the antidepressant activity. GC-MS analysis of methanol extract of was performed to ascertain the chemical constituents in the bioactive extract. The methanol extract of at dose of 100 and 200 mg/kg body weight, p.o. significantly reduced the total duration of immobility in the TST as well as FST (p
ISSN:1304-530X
2148-6247
DOI:10.4274/tjps.14622