Antibacterial, Antitubercular and Antiviral Activity Evaluations of Some Arylidenehydrazide Derivatives Bearing Imidazo[2,1- b ]thiazole Moiety

The aim of this study was to determine the probable antibacterial, antitubercular, and antiviral activities of some -arylidene-(6-(4-chlorophenyl)imidazo[2,1- ]thiazol-3-yl) acetic acid hydrazides . Further structural optimization of the identified lead structures can lead us to new more active potential antibacterial, antitubercular, and antiviral agents. Antibacterial activities of the title compounds against ATCC 29213, ATCC 27853 and ATCC 25922. These molecules were also evaluated for their antitubercular activity against H37Rv (ATCC 27294) using the BACTEC 460 radiometric system and BACTEC 12B medium. Moreover, all the compounds were also evaluated against some DNA and RNA viruses in Madin-Darby Canine Kidney, Crandell-Rees Feline Kidney (CRFK), Vero, human embryonic lung (HEL) and HeLa cells. Among the tested compounds, displayed the highest efficacy against and . Compound , 5-nitro-2-furfurylidene derivative showed the highest antituberculosis activity (IC : 6.16 µg/mL and IC : 14.390 µg/mL). Compound showed the most potent antiviral activity against feline corona virus in CRFK cell cultures (antiviral EC : 7.5 µM and SI>13). Furthermore, compounds and displayed activity against herpes simplex virus-1 and vaccinia virus in HEL cell cultures (antiviral EC values of 9; 16 and 20; 14 µM, respectively). On the basis of aforementioned results, it can be conluded that imidazo[2,1- ]thiazole derivatives bearing hydrazone moieties serve as promising chemical probes to design therapeutic agents with antibacterial, antitubercular, and antiviral properties.