Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

Among 1376 patients with Covid-19 admitted to a New York City hospital, 59% were treated with hydroxychloroquine. Patients selected for treatment were more severely ill. After adjustment for patients’ baseline characteristics, there was no significant association between hydroxychloroquine use and i...

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Veröffentlicht in:	The New England journal of medicine 2020-06, Vol.382 (25), p.2411-2418
Hauptverfasser:	Geleris, Joshua, Sun, Yifei, Platt, Jonathan, Zucker, Jason, Baldwin, Matthew, Hripcsak, George, Labella, Angelena, Manson, Daniel K, Kubin, Christine, Barr, R. Graham, Sobieszczyk, Magdalena E, Schluger, Neil W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Betacoronavirus Blood pressure Clinical trials Coronavirus Infections - drug therapy Coronavirus Infections - mortality Coronaviruses COVID-19 COVID-19 Drug Treatment Data warehouses Death Drug administration Drug dosages Emergency medical care Female Hospitalization Hospitals Humans Hydroxychloroquine Hydroxychloroquine - therapeutic use Immunomodulators Intubation Intubation - statistics & numerical data Laboratories Male Middle Aged New York City Observational studies Original Oxygen Oxygen saturation Pandemics Patients Pneumonia, Viral - drug therapy Pneumonia, Viral - mortality Probability Propensity Score SARS-CoV-2 Sensitivity analysis Severe acute respiratory syndrome coronavirus 2 Treatment Failure Vital signs
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Beschreibung
Zusammenfassung:	Among 1376 patients with Covid-19 admitted to a New York City hospital, 59% were treated with hydroxychloroquine. Patients selected for treatment were more severely ill. After adjustment for patients’ baseline characteristics, there was no significant association between hydroxychloroquine use and intubation or death (hazard ratio, 1.04; 95% CI, 0.82 to 1.32).
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2012410