Clinical characteristics and risk factors of tigecycline-associated hypofibrinogenaemia in critically ill patients

Purpose To analyze the clinical features and risk factors of tigecycline-associated hypofibrinogenaemia and study whether cefoperazone/sulbactam combined with tigecycline aggravates coagulopathy or hypofibrinogenaemia. Methods A retrospective case–control study of patients with severe infection who...

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Veröffentlicht in:	European journal of clinical pharmacology 2020-07, Vol.76 (7), p.913-922
Hauptverfasser:	Hu, Juan, Xiao, Yong-hong, Zheng, Yi, Lai, Yang-xiao, Fang, Xue-ling, Fang, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Afibrinogenemia - blood Afibrinogenemia - chemically induced Afibrinogenemia - epidemiology Aged Aged, 80 and over Anti-Bacterial Agents - adverse effects Bacterial Infections - blood Bacterial Infections - drug therapy Bacterial Infections - epidemiology Biomedical and Life Sciences Biomedicine Blood Coagulation Tests Case-Control Studies Cefoperazone Cefoperazone - therapeutic use Clinical Trial Critical Illness Female Fibrinogen Humans Infections Intra-abdominal infection Male Middle Aged Multivariate analysis Patients Pharmacology/Toxicology Retrospective Studies Risk Factors Sepsis Sulbactam Sulbactam - therapeutic use Tigecycline Tigecycline - adverse effects
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Zusammenfassung:	Purpose To analyze the clinical features and risk factors of tigecycline-associated hypofibrinogenaemia and study whether cefoperazone/sulbactam combined with tigecycline aggravates coagulopathy or hypofibrinogenaemia. Methods A retrospective case–control study of patients with severe infection who were treated with tigecycline was conducted. Patients were assigned to the hypofibrinogenaemia group (
ISSN:	0031-6970 1432-1041
DOI:	10.1007/s00228-020-02860-w