Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia
Objective To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD). Study design Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ post...
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| Veröffentlicht in: | Journal of perinatology 2020-01, Vol.40 (1), p.149-156 |
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| creator | Vyas-Read, Shilpa Wymore, Erica M. Zaniletti, Isabella Murthy, Karna Padula, Michael A. Truog, William E. Engle, William A. Savani, Rashmin C. Yallapragada, Sushmita Logan, J. Wells Zhang, Huayan Hysinger, Erik B. Grover, Theresa R. Natarajan, Girija Nelin, Leif D. Porta, Nicolas F. M. Potoka, Karin P. DiGeronimo, Robert Lagatta, Joanne M. |
| description | Objective
To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD).
Study design
Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing.
Results
Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both
p
|
| doi_str_mv | 10.1038/s41372-019-0508-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7222140</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A623968761</galeid><sourcerecordid>A623968761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c568t-ae7d6b5dea0836303916b81c0b6c54bbcddc25a53c28df9ae6a9f099479091093</originalsourceid><addsrcrecordid>eNp1kk1rFTEUhgdR7LX6A9zIgCBupuZjkkw2Qil-QcGNXYdM5sydlEwyJpmW--_N9da2V5QsAjnP--acw1tVrzE6w4h2H1KLqSANwrJBDHUNe1JtcCt4w1hLn1YbJFradLTlJ9WLlK4R2hfF8-qEYiaQkHJTwVW2zuZdHcYazBSMjoMN26iXaVdbXy8RBmuy9dt6DjHr32x5t37UPqf61uapTnADEeo-Bl8sltXNweu4q4ddWpxOVr-sno3aJXh1d59WV58__bj42lx-__Lt4vyyMYx3udEgBt6zATTqKKeISsz7DhvUc8PavjfDYAjTjBrSDaPUwLUckZStkEhiJOlp9fHgu6z9DIMBn6N2aol2Lv2ooK06rng7qW24UYIQgltUDN7fGcTwc4WU1WyTAee0h7AmRYiUgnPGaEHf_oVehzX6Mp4ilJSOOOXigdpqB6psLZR_zd5UnXNCJe8Ex4U6-wdVzgCzNcHDaMv7keDdI8EE2uUpBbdmG3w6BvEBNDGkFGG8XwZGah8idQiRKiFS-xApVjRvHm_xXvEnNQUgByCVkt9CfBj9_66_AFm40t8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2327906367</pqid></control><display><type>article</type><title>Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Vyas-Read, Shilpa ; Wymore, Erica M. ; Zaniletti, Isabella ; Murthy, Karna ; Padula, Michael A. ; Truog, William E. ; Engle, William A. ; Savani, Rashmin C. ; Yallapragada, Sushmita ; Logan, J. Wells ; Zhang, Huayan ; Hysinger, Erik B. ; Grover, Theresa R. ; Natarajan, Girija ; Nelin, Leif D. ; Porta, Nicolas F. M. ; Potoka, Karin P. ; DiGeronimo, Robert ; Lagatta, Joanne M.</creator><creatorcontrib>Vyas-Read, Shilpa ; Wymore, Erica M. ; Zaniletti, Isabella ; Murthy, Karna ; Padula, Michael A. ; Truog, William E. ; Engle, William A. ; Savani, Rashmin C. ; Yallapragada, Sushmita ; Logan, J. Wells ; Zhang, Huayan ; Hysinger, Erik B. ; Grover, Theresa R. ; Natarajan, Girija ; Nelin, Leif D. ; Porta, Nicolas F. M. ; Potoka, Karin P. ; DiGeronimo, Robert ; Lagatta, Joanne M. ; Children’s Hospitals Neonatal Consortium Severe BPD Focus Group ; on behalf of the Children’s Hospitals Neonatal Consortium Severe BPD Focus Group</creatorcontrib><description>Objective
To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD).
Study design
Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing.
Results
Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both
p
< 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2–3.0; RVSP OR 2.2, 95% CI 1.1–4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality.
Conclusions
Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-019-0508-5</identifier><identifier>PMID: 31570799</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/409 ; 692/699/1785 ; Age ; Analysis ; Babies ; Blood Pressure ; Bronchopulmonary Dysplasia - diagnostic imaging ; Bronchopulmonary Dysplasia - mortality ; Dysplasia ; Echocardiography ; Female ; Health aspects ; Heart Septal Defects, Ventricular - diagnostic imaging ; Hospital Mortality ; Hospitals ; Humans ; Hypertension ; Infant mortality ; Infant, Newborn ; Infant, Premature ; Infants ; Infants (Newborn) ; Intensive Care Units, Neonatal ; Lung diseases ; Male ; Medicine ; Medicine & Public Health ; Mortality ; Pediatric Surgery ; Pediatrics ; Prognosis ; Truog, William E ; Ultrasonic imaging ; Ventilators ; Ventricular Septum - anatomy & histology ; Ventricular Septum - diagnostic imaging</subject><ispartof>Journal of perinatology, 2020-01, Vol.40 (1), p.149-156</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2019</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c568t-ae7d6b5dea0836303916b81c0b6c54bbcddc25a53c28df9ae6a9f099479091093</citedby><cites>FETCH-LOGICAL-c568t-ae7d6b5dea0836303916b81c0b6c54bbcddc25a53c28df9ae6a9f099479091093</cites><orcidid>0000-0002-6135-8503 ; 0000-0003-2050-5930 ; 0000-0002-9533-5422</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-019-0508-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-019-0508-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31570799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vyas-Read, Shilpa</creatorcontrib><creatorcontrib>Wymore, Erica M.</creatorcontrib><creatorcontrib>Zaniletti, Isabella</creatorcontrib><creatorcontrib>Murthy, Karna</creatorcontrib><creatorcontrib>Padula, Michael A.</creatorcontrib><creatorcontrib>Truog, William E.</creatorcontrib><creatorcontrib>Engle, William A.</creatorcontrib><creatorcontrib>Savani, Rashmin C.</creatorcontrib><creatorcontrib>Yallapragada, Sushmita</creatorcontrib><creatorcontrib>Logan, J. Wells</creatorcontrib><creatorcontrib>Zhang, Huayan</creatorcontrib><creatorcontrib>Hysinger, Erik B.</creatorcontrib><creatorcontrib>Grover, Theresa R.</creatorcontrib><creatorcontrib>Natarajan, Girija</creatorcontrib><creatorcontrib>Nelin, Leif D.</creatorcontrib><creatorcontrib>Porta, Nicolas F. M.</creatorcontrib><creatorcontrib>Potoka, Karin P.</creatorcontrib><creatorcontrib>DiGeronimo, Robert</creatorcontrib><creatorcontrib>Lagatta, Joanne M.</creatorcontrib><creatorcontrib>Children’s Hospitals Neonatal Consortium Severe BPD Focus Group</creatorcontrib><creatorcontrib>on behalf of the Children’s Hospitals Neonatal Consortium Severe BPD Focus Group</creatorcontrib><title>Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD).
Study design
Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing.
Results
Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both
p
< 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2–3.0; RVSP OR 2.2, 95% CI 1.1–4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality.
Conclusions
Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.</description><subject>692/308/409</subject><subject>692/699/1785</subject><subject>Age</subject><subject>Analysis</subject><subject>Babies</subject><subject>Blood Pressure</subject><subject>Bronchopulmonary Dysplasia - diagnostic imaging</subject><subject>Bronchopulmonary Dysplasia - mortality</subject><subject>Dysplasia</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Health aspects</subject><subject>Heart Septal Defects, Ventricular - diagnostic imaging</subject><subject>Hospital Mortality</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infant mortality</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants</subject><subject>Infants (Newborn)</subject><subject>Intensive Care Units, Neonatal</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Truog, William E</subject><subject>Ultrasonic imaging</subject><subject>Ventilators</subject><subject>Ventricular Septum - anatomy & histology</subject><subject>Ventricular Septum - diagnostic imaging</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1rFTEUhgdR7LX6A9zIgCBupuZjkkw2Qil-QcGNXYdM5sydlEwyJpmW--_N9da2V5QsAjnP--acw1tVrzE6w4h2H1KLqSANwrJBDHUNe1JtcCt4w1hLn1YbJFradLTlJ9WLlK4R2hfF8-qEYiaQkHJTwVW2zuZdHcYazBSMjoMN26iXaVdbXy8RBmuy9dt6DjHr32x5t37UPqf61uapTnADEeo-Bl8sltXNweu4q4ddWpxOVr-sno3aJXh1d59WV58__bj42lx-__Lt4vyyMYx3udEgBt6zATTqKKeISsz7DhvUc8PavjfDYAjTjBrSDaPUwLUckZStkEhiJOlp9fHgu6z9DIMBn6N2aol2Lv2ooK06rng7qW24UYIQgltUDN7fGcTwc4WU1WyTAee0h7AmRYiUgnPGaEHf_oVehzX6Mp4ilJSOOOXigdpqB6psLZR_zd5UnXNCJe8Ex4U6-wdVzgCzNcHDaMv7keDdI8EE2uUpBbdmG3w6BvEBNDGkFGG8XwZGah8idQiRKiFS-xApVjRvHm_xXvEnNQUgByCVkt9CfBj9_66_AFm40t8</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Vyas-Read, Shilpa</creator><creator>Wymore, Erica M.</creator><creator>Zaniletti, Isabella</creator><creator>Murthy, Karna</creator><creator>Padula, Michael A.</creator><creator>Truog, William E.</creator><creator>Engle, William A.</creator><creator>Savani, Rashmin C.</creator><creator>Yallapragada, Sushmita</creator><creator>Logan, J. Wells</creator><creator>Zhang, Huayan</creator><creator>Hysinger, Erik B.</creator><creator>Grover, Theresa R.</creator><creator>Natarajan, Girija</creator><creator>Nelin, Leif D.</creator><creator>Porta, Nicolas F. M.</creator><creator>Potoka, Karin P.</creator><creator>DiGeronimo, Robert</creator><creator>Lagatta, Joanne M.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6135-8503</orcidid><orcidid>https://orcid.org/0000-0003-2050-5930</orcidid><orcidid>https://orcid.org/0000-0002-9533-5422</orcidid></search><sort><creationdate>20200101</creationdate><title>Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia</title><author>Vyas-Read, Shilpa ; Wymore, Erica M. ; Zaniletti, Isabella ; Murthy, Karna ; Padula, Michael A. ; Truog, William E. ; Engle, William A. ; Savani, Rashmin C. ; Yallapragada, Sushmita ; Logan, J. Wells ; Zhang, Huayan ; Hysinger, Erik B. ; Grover, Theresa R. ; Natarajan, Girija ; Nelin, Leif D. ; Porta, Nicolas F. M. ; Potoka, Karin P. ; DiGeronimo, Robert ; Lagatta, Joanne M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c568t-ae7d6b5dea0836303916b81c0b6c54bbcddc25a53c28df9ae6a9f099479091093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/308/409</topic><topic>692/699/1785</topic><topic>Age</topic><topic>Analysis</topic><topic>Babies</topic><topic>Blood Pressure</topic><topic>Bronchopulmonary Dysplasia - diagnostic imaging</topic><topic>Bronchopulmonary Dysplasia - mortality</topic><topic>Dysplasia</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Health aspects</topic><topic>Heart Septal Defects, Ventricular - diagnostic imaging</topic><topic>Hospital Mortality</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Infant mortality</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infants</topic><topic>Infants (Newborn)</topic><topic>Intensive Care Units, Neonatal</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Truog, William E</topic><topic>Ultrasonic imaging</topic><topic>Ventilators</topic><topic>Ventricular Septum - anatomy & histology</topic><topic>Ventricular Septum - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vyas-Read, Shilpa</creatorcontrib><creatorcontrib>Wymore, Erica M.</creatorcontrib><creatorcontrib>Zaniletti, Isabella</creatorcontrib><creatorcontrib>Murthy, Karna</creatorcontrib><creatorcontrib>Padula, Michael A.</creatorcontrib><creatorcontrib>Truog, William E.</creatorcontrib><creatorcontrib>Engle, William A.</creatorcontrib><creatorcontrib>Savani, Rashmin C.</creatorcontrib><creatorcontrib>Yallapragada, Sushmita</creatorcontrib><creatorcontrib>Logan, J. Wells</creatorcontrib><creatorcontrib>Zhang, Huayan</creatorcontrib><creatorcontrib>Hysinger, Erik B.</creatorcontrib><creatorcontrib>Grover, Theresa R.</creatorcontrib><creatorcontrib>Natarajan, Girija</creatorcontrib><creatorcontrib>Nelin, Leif D.</creatorcontrib><creatorcontrib>Porta, Nicolas F. M.</creatorcontrib><creatorcontrib>Potoka, Karin P.</creatorcontrib><creatorcontrib>DiGeronimo, Robert</creatorcontrib><creatorcontrib>Lagatta, Joanne M.</creatorcontrib><creatorcontrib>Children’s Hospitals Neonatal Consortium Severe BPD Focus Group</creatorcontrib><creatorcontrib>on behalf of the Children’s Hospitals Neonatal Consortium Severe BPD Focus Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vyas-Read, Shilpa</au><au>Wymore, Erica M.</au><au>Zaniletti, Isabella</au><au>Murthy, Karna</au><au>Padula, Michael A.</au><au>Truog, William E.</au><au>Engle, William A.</au><au>Savani, Rashmin C.</au><au>Yallapragada, Sushmita</au><au>Logan, J. Wells</au><au>Zhang, Huayan</au><au>Hysinger, Erik B.</au><au>Grover, Theresa R.</au><au>Natarajan, Girija</au><au>Nelin, Leif D.</au><au>Porta, Nicolas F. M.</au><au>Potoka, Karin P.</au><au>DiGeronimo, Robert</au><au>Lagatta, Joanne M.</au><aucorp>Children’s Hospitals Neonatal Consortium Severe BPD Focus Group</aucorp><aucorp>on behalf of the Children’s Hospitals Neonatal Consortium Severe BPD Focus Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>40</volume><issue>1</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective
To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD).
Study design
Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing.
Results
Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both
p
< 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2–3.0; RVSP OR 2.2, 95% CI 1.1–4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality.
Conclusions
Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>31570799</pmid><doi>10.1038/s41372-019-0508-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6135-8503</orcidid><orcidid>https://orcid.org/0000-0003-2050-5930</orcidid><orcidid>https://orcid.org/0000-0002-9533-5422</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2020-01, Vol.40 (1), p.149-156 |
| issn | 0743-8346 1476-5543 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7222140 |
| source | MEDLINE; SpringerLink Journals |
| subjects | 692/308/409 692/699/1785 Age Analysis Babies Blood Pressure Bronchopulmonary Dysplasia - diagnostic imaging Bronchopulmonary Dysplasia - mortality Dysplasia Echocardiography Female Health aspects Heart Septal Defects, Ventricular - diagnostic imaging Hospital Mortality Hospitals Humans Hypertension Infant mortality Infant, Newborn Infant, Premature Infants Infants (Newborn) Intensive Care Units, Neonatal Lung diseases Male Medicine Medicine & Public Health Mortality Pediatric Surgery Pediatrics Prognosis Truog, William E Ultrasonic imaging Ventilators Ventricular Septum - anatomy & histology Ventricular Septum - diagnostic imaging |
| title | Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T00%3A44%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Utility%20of%20echocardiography%20in%20predicting%20mortality%20in%20infants%20with%20severe%20bronchopulmonary%20dysplasia&rft.jtitle=Journal%20of%20perinatology&rft.au=Vyas-Read,%20Shilpa&rft.aucorp=Children%E2%80%99s%20Hospitals%20Neonatal%20Consortium%20Severe%20BPD%20Focus%20Group&rft.date=2020-01-01&rft.volume=40&rft.issue=1&rft.spage=149&rft.epage=156&rft.pages=149-156&rft.issn=0743-8346&rft.eissn=1476-5543&rft_id=info:doi/10.1038/s41372-019-0508-5&rft_dat=%3Cgale_pubme%3EA623968761%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2327906367&rft_id=info:pmid/31570799&rft_galeid=A623968761&rfr_iscdi=true |