Real-time PCR-based SARS-CoV-2 detection in Canadian laboratories

Real-time PCR-based SARS-CoV-2 detection in Canadian laboratories

With emergence of pandemic COVID-19, rapid and accurate diagnostic testing is essential. This study compared laboratory-developed tests (LDTs) used for the detection of SARS-CoV-2 in Canadian hospital and public health laboratories, and some commercially available real-time RT-PCR assays. Overall, a...

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Veröffentlicht in:Journal of clinical virology 2020-07, Vol.128, p.104433-104433, Article 104433
Hauptverfasser: LeBlanc, Jason J., Gubbay, Jonathan B., Li, Yan, Needle, Robert, Arneson, Sandra Radons, Marcino, Dionne, Charest, Hugues, Desnoyers, Guillaume, Dust, Kerry, Fattouh, Ramzi, Garceau, Richard, German, Gregory, Hatchette, Todd F, Kozak, Robert A., Krajden, Mel, Kuschak, Theodore, Lang, Amanda L.S., Levett, Paul, Mazzulli, Tony, McDonald, Ryan, Mubareka, Samira, Prystajecky, Natalie, Rutherford, Candy, Smieja, Marek, Yu, Yang, Zahariadis, George, Zelyas, Nathan, Bastien, Nathalie
Format: Artikel
Sprache:eng
Schlagworte:
Betacoronavirus - isolation & purification
Canada
Clinical Laboratory Techniques - methods
Coronavirus
Coronavirus Infections - diagnosis
Coronavirus Infections - virology
COVID-19
COVID-19 Testing
COVID-19 Vaccines
Humans
Laboratories
Limit of Detection
Molecular
NAAT
Pandemics
PCR
Pneumonia, Viral - diagnosis
Pneumonia, Viral - virology
Real-Time Polymerase Chain Reaction - methods
SARS-CoV-2
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Zusammenfassung:With emergence of pandemic COVID-19, rapid and accurate diagnostic testing is essential. This study compared laboratory-developed tests (LDTs) used for the detection of SARS-CoV-2 in Canadian hospital and public health laboratories, and some commercially available real-time RT-PCR assays. Overall, analytical sensitivities were equivalent between LDTs and most commercially available methods.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2020.104433