Integrative Modeling of a Sin3/HDAC Complex Sub-structure

Sin3/HDAC complexes function by deacetylating histones, condensing chromatin, and modulating gene expression. Although components used to build these complexes have been well defined, we still have only a limited understanding of the structure of the Sin3/HDAC subunits assembled around the scaffoldi...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-04, Vol.31 (2), p.107516-107516, Article 107516
Hauptverfasser:	Banks, Charles A.S., Zhang, Ying, Miah, Sayem, Hao, Yan, Adams, Mark K., Wen, Zhihui, Thornton, Janet L., Florens, Laurence, Washburn, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	chromatin crosslinking distance restraints DSSO HDAC HEK293 Cells Histone Deacetylase 1 - metabolism Histone Deacetylase 2 - metabolism Histone Deacetylases - metabolism Humans Mass Spectrometry - methods protein docking proteomics Repressor Proteins - metabolism Sin3 Sin3 Histone Deacetylase and Corepressor Complex - genetics Sin3 Histone Deacetylase and Corepressor Complex - metabolism Sin3 Histone Deacetylase and Corepressor Complex - physiology structural modeling XL-MS
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