Maternal Glucose Concentrations in Early Pregnancy and Cardiometabolic Risk Factors in Childhood

Objective This study aimed to examine the associations of maternal early‐pregnancy glucose and insulin concentrations with offspring cardiometabolic risk factors and fat distribution. Methods In a population‐based prospective cohort study among 3,737 mothers and their children, random maternal glucose and insulin concentrations were measured at a median gestational age of 13.2 (95% range 10.5‐17.1) weeks. Childhood fat, blood pressure, and blood concentrations of lipids, glucose, and insulin at the age of 10 years were measured. Results Higher maternal early‐pregnancy glucose and insulin concentrations were associated with a higher risk of childhood overweight, and higher maternal early‐pregnancy insulin concentrations were associated with an increased childhood risk of clustering of cardiometabolic risk factors (all P