Enhanced oral bioavailability and anti-diabetic activity of canagliflozin through a spray dried lipid based oral delivery: a novel paradigm

Aim Canagliflozin (CFZ), a novel SGLT II antagonist, exhibits erratic absorption after oral administration. The current study entails development and evaluation of spray dried lipid based formulation (solid SMEDDS) for enhancing oral bioavailability and anti-diabetic activity of CFZ. Methods Solid S...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Daru 2020-06, Vol.28 (1), p.191-208
Hauptverfasser:	Singh, Dilpreet, Singh, Amrit Pal, Singh, Drishtant, Kesavan, Anup Kumar, Arora, Saroj, Tiwary, Ashok K., Bedi, Neena
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aluminum Compounds - administration & dosage Aluminum Compounds - chemistry Aluminum Compounds - pharmacokinetics Analysis Animals Biological Availability Biomedical and Life Sciences Biomedicine Canagliflozin Canagliflozin - administration & dosage Canagliflozin - blood Canagliflozin - chemistry Canagliflozin - pharmacokinetics Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - urine Drug Delivery Systems Drug Liberation Electron microscopy Glucose Glycosuria Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - blood Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacokinetics Intestinal Absorption Kidney - drug effects Kidney - metabolism Lipids - administration & dosage Lipids - chemistry Lipids - pharmacokinetics Magnesium Compounds - administration & dosage Magnesium Compounds - chemistry Magnesium Compounds - pharmacokinetics Marketing Medicinal Chemistry Microscopy Novels Permeability Pharmaceutic Aids - administration & dosage Pharmaceutic Aids - chemistry Pharmaceutic Aids - pharmacokinetics Pharmaceutical Sciences/Technology Pharmacology/Toxicology Photographic industry Rats, Wistar Research Article Silicates - administration & dosage Silicates - chemistry Silicates - pharmacokinetics Sodium-Glucose Transporter 2 - metabolism Spray Drying
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!