Immune imbalance and activation are associated with lower lung function in youth with perinatally acquired HIV

High CD8 T-cells and low CD4/CD8 are associated with lower lung function among youth living with perinatally-acquired HIV, despite antiretroviral therapy and CD4 preservation/reconstitution. Understanding these underlying mechanisms is critical to mitigate lung function impairment.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of allergy and clinical immunology 2020-05, Vol.145 (5), p.1473-1476
Hauptverfasser:	Attia, Engi F., Jacobson, Denise, Yu, Wendy, Crowell, Claudia S., Maleche-Obimbo, Elizabeth, Williams, Paige L., West, T. Eoin, Burchett, Sandra K., Kattan, Meyer, Colin, Andrew A., Eskander, Sherry, Chung, Michael H., Crothers, Kristina, Shearer, William T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Child Female Forced Expiratory Volume HIV Infections - immunology HIV Infections - physiopathology HIV Infections - transmission Humans Infectious Disease Transmission, Vertical Kenya Lung - physiopathology Lymphocyte Count Male United States Young Adult
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Beschreibung
Zusammenfassung:	High CD8 T-cells and low CD4/CD8 are associated with lower lung function among youth living with perinatally-acquired HIV, despite antiretroviral therapy and CD4 preservation/reconstitution. Understanding these underlying mechanisms is critical to mitigate lung function impairment.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2019.12.890