Activation of Inward Rectifier K+ Channel 2.1 by PDGF-BB in Rat Vascular Smooth Muscle Cells through Protein Kinase A

Platelet-derived growth factor-BB (PDGF-BB) can induce the proliferation, migration, and phenotypic modulation of vascular smooth muscle cells (VSMCs). We used patch clamp methods to study the effects of PDGF-BB on inward rectifier K+ channel 2.1 (Kir2.1) channels in rat thoracic aorta VSMCs (RASMCs...

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Veröffentlicht in:	BioMed research international 2020, Vol.2020 (2020), p.1-9
Hauptverfasser:	Qiao, Yong, Liu, Bo, Yan, Gaoliang, Luo, Erfei, Wang, Dong, Tang, Chengchun, Hou, Jiantong
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine Adenylate cyclase AKT protein Animals Aorta Aorta, Thoracic - cytology Becaplermin - pharmacology Cell proliferation Cells, Cultured Channels Colforsin - pharmacology Coronary vessels Cyclic AMP-Dependent Protein Kinases - metabolism Enzyme inhibitors Forskolin Gene expression Genotype & phenotype Growth factors HEK293 Cells Humans Kinases Laboratory animals Male Muscle, Smooth, Vascular - cytology Muscles Platelet-derived growth factor Platelet-derived growth factor BB Potassium channels Potassium channels (inwardly-rectifying) Potassium Channels, Inwardly Rectifying - drug effects Potassium Channels, Inwardly Rectifying - metabolism Protein kinase A Protein kinase A inhibitors Proteins Rats Rats, Sprague-Dawley Rectifiers Rodents Signal Transduction - drug effects Smooth muscle Stimulation Thermal cycling Thorax
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Zusammenfassung:	Platelet-derived growth factor-BB (PDGF-BB) can induce the proliferation, migration, and phenotypic modulation of vascular smooth muscle cells (VSMCs). We used patch clamp methods to study the effects of PDGF-BB on inward rectifier K+ channel 2.1 (Kir2.1) channels in rat thoracic aorta VSMCs (RASMCs). PDGF-BB (25 ng/mL) increased Kir2.x currents (−11.81±2.47 pA/pF, P
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2020/4370832