KTN1 variants and risk for attention deficit hyperactivity disorder

Individuals with attention deficit hyperactivity disorder (ADHD) show gray matter volume (GMV) reduction in the putamen. KTN1 variants may regulate kinectin 1 expression in the putamen and influence putamen structure and function. We aim to test the hypothesis that the KTN1 variants may represent a genetic risk factor of ADHD. Two independent family‐based Caucasian samples were analyzed, including 922 parent–child trios (a total of 2,757 subjects with 924 ADHD children) and 735 parent–child trios (a total of 1,383 subjects with 613 ADHD children). The association between ADHD and a total of 143 KTN1 SNPs was analyzed in the first sample, and the nominally‐significant (p