Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats

Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats

Background: Liothyronine (LT3) has limited short-term clinical applications, all of which aim at suppressing thyrotropin (TSH) secretion. A more controversial application is chronic administration along with levothyroxine in the treatment of hypothyroidism. Long-term treatment with LT3 is complicate...

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Veröffentlicht in:Thyroid (New York, N.Y.) N.Y.), 2018-11, Vol.28 (11), p.1425-1433
Hauptverfasser: Da Conceição, Rodrigo R., Fernandes, Gustavo W., Fonseca, Tatiana L., Bocco, Barbara M.L.C., Bianco, Antonio C.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Hypothyroidism - blood
Hypothyroidism - drug therapy
Male
Original Studies
Rats
Rats, Wistar
Thyrotropin - blood
Treatment Outcome
Triiodothyronine - blood
Triiodothyronine - therapeutic use
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Zusammenfassung:Background: Liothyronine (LT3) has limited short-term clinical applications, all of which aim at suppressing thyrotropin (TSH) secretion. A more controversial application is chronic administration along with levothyroxine in the treatment of hypothyroidism. Long-term treatment with LT3 is complicated by its unique pharmacokinetics that result in a substantial triiodothyronine (T3) peak in the blood three to four hours after oral dosing. This is a significant problem, given that T3 levels in the blood are normally stable, varying by
ISSN:1050-7256
1557-9077
DOI:10.1089/thy.2018.0205