Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia

Mycobacterium tuberculosis (MTB) is commonly used as a model to study pathogenicity and multiple drug resistance in bacteria. These MTB characteristics are highly dependent on the evolution and phylogeography of the bacterium. In this paper, we describe 15 new genomes of multidrug-resistant MTB (MDRTB) from Malaysia. The assessments and annotations on the genome assemblies suggest that strain differences are due to lineages and horizontal gene transfer during the course of evolution. The genomes show mutations listed in current drug resistance databases and global MTB collections. This genome data will augment existing information available for comparative genomic studies to understand MTB drug resistance mechanisms and evolution. Measurement(s) DNA • genome • sequence_assembly • sequence feature annotation Technology Type(s) DNA sequencing • sequence assembly process • sequence annotation Factor Type(s) strain Sample Characteristic - Organism Mycobacterium tuberculosis Sample Characteristic - Location Malaysia Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.12130008