A metal-free aromative cascade for the synthesis of diverse heterocycles

A metal-free aromative cascade for the synthesis of diverse heterocycles

A metal-free aromative cascade has been developed for the synthesis of diverse heterocycles from readily accessible hydroxy/aminochalcones and acid/alkyl halides. The cascade being by a base-mediated intramolecular aldol cyclization/dehydration sequence to provide a triene, which sets the stage for...

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Veröffentlicht in:Organic chemistry frontiers an international journal of organic chemistry 2020-04, Vol.7 (7), p.913-918
Hauptverfasser: Schlitzer, Steven C, Arunprasath, Dhanarajan, Stevens, Katelyn G, Sharma, Indrajeet
Format: Artikel
Sprache:eng
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Zusammenfassung:A metal-free aromative cascade has been developed for the synthesis of diverse heterocycles from readily accessible hydroxy/aminochalcones and acid/alkyl halides. The cascade being by a base-mediated intramolecular aldol cyclization/dehydration sequence to provide a triene, which sets the stage for a 6π-electrocyclization/oxidative aromatization to access diverse heterocyclic scaffolds.
ISSN:2052-4110
2052-4110
DOI:10.1039/c9qo01336a