Characterizing the BCR repertoire in immune-mediated diseases

Characterizing the BCR repertoire in immune-mediated diseases

B cells can assume protective or pathogenic roles in immune-mediated diseases (IMDs). Analysis of the B cell receptor (BCR) repertoires in six IMDs provides insights into the diversity of B cell repertoires across diseases as well as into potential pathological mechanisms and the effects of differen...

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Veröffentlicht in:Nature reviews. Rheumatology 2020-01, Vol.16 (1), p.7-8
Hauptverfasser: Ramadoss, Nitya S., Robinson, William H.
Format: Artikel
Sprache:eng
Schlagworte:
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Antigens
B cells
B-cell receptor
B-Lymphocytes
Belimumab
Humans
Immune System Diseases
Lymphocytes B
Medicine
Medicine & Public Health
News & Views
news-and-views
Receptors, Antigen, B-Cell
Rheumatology
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Beschreibung
Zusammenfassung:B cells can assume protective or pathogenic roles in immune-mediated diseases (IMDs). Analysis of the B cell receptor (BCR) repertoires in six IMDs provides insights into the diversity of B cell repertoires across diseases as well as into potential pathological mechanisms and the effects of different treatments.
ISSN:1759-4790
1759-4804
DOI:10.1038/s41584-019-0339-y