In Vivo Antiplasmodial Activity of Different Solvent Extracts of Myrianthus libericus Stem Bark and Its Constituents in Plasmodium berghei-Infected Mice

In Vivo Antiplasmodial Activity of Different Solvent Extracts of Myrianthus libericus Stem Bark and Its Constituents in Plasmodium berghei-Infected Mice

The emergence and resurgence of P. falciparum resistance to generations of antimalarial drugs have prompted the search for new, effective, and safe antimalarial agents. This study aimed at investigating the in vivo antiplasmodial activity of the 70% hydroethanolic extract and constituents of the ste...

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Veröffentlicht in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-10
Hauptverfasser: Adjei, Silas, Forkuo, Arnold Donkor, Amponsah, Isaac Kingsley, Asante-Kwatia, Evelyn, Mensah, Abraham Yeboah, Baah, Michael Kwesi, Harley, Benjamin Kingsley
Format: Artikel
Sprache:eng
Schlagworte:
Acetic acid
Alternative medicine
Antimalarial agents
Antimalarials
Antiprotozoal agents
Bark
Blood
Column chromatography
Esters
Ethyl acetate
Ethylenediaminetetraacetic acid
Herbal medicine
Hypothermia
Infections
Laboratory animals
Malaria
Medical research
Methods
Parasites
Plasmodium falciparum
Solvents
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Zusammenfassung:The emergence and resurgence of P. falciparum resistance to generations of antimalarial drugs have prompted the search for new, effective, and safe antimalarial agents. This study aimed at investigating the in vivo antiplasmodial activity of the 70% hydroethanolic extract and constituents of the stem bark of Myrianthus libericus based on its ethnomedicinal use as an antimalarial agent. The antiplasmodial activity was assessed in Swiss albino mice employing the 4-day suppressive and Rane’s tests. MLB significantly (p
ISSN:1741-427X
1741-4288
DOI:10.1155/2020/8703197