Primary cilia control glucose homeostasis via islet paracrine interactions

Pancreatic islets regulate glucose homeostasis through coordinated actions of hormone-secreting cells. What underlies the function of the islet as a unit is the close approximation and communication among heterogeneous cell populations, but the structural mediators of islet cellular cross talk remai...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-04, Vol.117 (16), p.8912-8923
Hauptverfasser:	Hughes, Jing W., Cho, Jung Hoon, Conway, Hannah E., DiGruccio, Michael R., Ng, Xue Wen, Roseman, Henry F., Abreu, Damien, Urano, Fumihiko, Piston, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cells Biological Sciences Calcium - metabolism Calcium influx Cell Communication - physiology Cellular structure Chemoreception Cilia Cilia - genetics Cilia - metabolism Cilia - pathology Clonal deletion Crosstalk Diabetes Diabetes mellitus Diabetes Mellitus - genetics Diabetes Mellitus - pathology Disease Models, Animal Energy Metabolism - physiology Female Glucagon-Secreting Cells - metabolism Glucose Glucose - metabolism Homeostasis Humans Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Male Mice Mice, Knockout Pancreas Paracrine signalling Perturbation Secretion Signal Transduction - physiology
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