Amantadine as a drug to mitigate the effects of COVID-19

The SARS-CoV-2 virus has spread around the world. At this time, there is no vaccine that can help people prevent the spread of coronavirus. We are proposing amantadine as a drug that can be used to mitigate the effects of the virus. It is demonstrated by docking models how amantadine can exert its a...

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Veröffentlicht in:	Medical hypotheses 2020-07, Vol.140, p.109755-109755, Article 109755
Hauptverfasser:	Aranda Abreu, Gonzalo Emiliano, Hernández Aguilar, María Elena, Herrera Covarrubias, Deissy, Rojas Durán, Fausto
Format:	Artikel
Sprache:	eng
Schlagworte:	Amantadine Amantadine - therapeutic use Betacoronavirus Coronavirus Envelope Proteins Coronavirus Infections - drug therapy COVID-19 Docking Humans Ion Channels - chemistry Ion Channels - drug effects Ligands Molecular Docking Simulation Pandemics Pneumonia, Viral - drug therapy Protein Conformation SARS-CoV-2 Viral Envelope Proteins - chemistry Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - drug effects Viroporin Viroporin Proteins
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Beschreibung
Zusammenfassung:	The SARS-CoV-2 virus has spread around the world. At this time, there is no vaccine that can help people prevent the spread of coronavirus. We are proposing amantadine as a drug that can be used to mitigate the effects of the virus. It is demonstrated by docking models how amantadine can exert its action on Coronavirus viroporin E.
ISSN:	0306-9877 1532-2777
DOI:	10.1016/j.mehy.2020.109755