Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus

New drugs or therapeutic combinations are urgently needed against Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against We show here that these compounds act synergistically with imipenem and cefoxitin and increase the bactericidal activity of the β-lactams agains...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2020-04, Vol.64 (5), p.AAC.02548-19
Hauptverfasser:	Raynaud, Clément, Daher, Wassim, Roquet-Banères, Françoise, Johansen, Matt D, Stec, Jozef, Onajole, Oluseye K, Ordway, Diane, Kozikowski, Alan P, Kremer, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology beta-Lactams - pharmacology Cefoxitin - pharmacology Colony Count, Microbial Drug Synergism Humans Imipenem - pharmacology Indoles - pharmacology Life Sciences Macrophages - microbiology Mechanisms of Action: Physiological Effects Microbial Sensitivity Tests Microbiology and Parasitology Mycobacterium abscessus - drug effects Mycobacterium Infections, Nontuberculous - drug therapy Mycobacterium Infections, Nontuberculous - microbiology
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Zusammenfassung:	New drugs or therapeutic combinations are urgently needed against Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against We show here that these compounds act synergistically with imipenem and cefoxitin and increase the bactericidal activity of the β-lactams against In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.02548-19