Outdoor Air Pollution and New-Onset Airway Disease. An Official American Thoracic Society Workshop Report

Although it is well accepted that air pollution exposure exacerbates preexisting airway disease, it has not been firmly established that long-term pollution exposure increases the risk of new-onset asthma or chronic obstruction pulmonary disease (COPD). This Workshop brought together experts on mech...

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Veröffentlicht in:Annals of the American Thoracic Society 2020-04, Vol.17 (4), p.387-398
Hauptverfasser: Thurston, George D, Balmes, John R, Garcia, Erika, Gilliland, Frank D, Rice, Mary B, Schikowski, Tamara, Van Winkle, Laura S, Annesi-Maesano, Isabella, Burchard, Esteban G, Carlsten, Christopher, Harkema, Jack R, Khreis, Haneen, Kleeberger, Steven R, Kodavanti, Urmila P, London, Stephanie J, McConnell, Rob, Peden, Dave B, Pinkerton, Kent E, Reibman, Joan, White, Carl W
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container_end_page 398
container_issue 4
container_start_page 387
container_title Annals of the American Thoracic Society
container_volume 17
creator Thurston, George D
Balmes, John R
Garcia, Erika
Gilliland, Frank D
Rice, Mary B
Schikowski, Tamara
Van Winkle, Laura S
Annesi-Maesano, Isabella
Burchard, Esteban G
Carlsten, Christopher
Harkema, Jack R
Khreis, Haneen
Kleeberger, Steven R
Kodavanti, Urmila P
London, Stephanie J
McConnell, Rob
Peden, Dave B
Pinkerton, Kent E
Reibman, Joan
White, Carl W
description Although it is well accepted that air pollution exposure exacerbates preexisting airway disease, it has not been firmly established that long-term pollution exposure increases the risk of new-onset asthma or chronic obstruction pulmonary disease (COPD). This Workshop brought together experts on mechanistic, epidemiological, and clinical aspects of airway disease to review current knowledge regarding whether air pollution is a causal factor in the development of asthma and/or COPD. Speakers presented recent evidence in their respective areas of expertise related to air pollution and new airway disease incidence, followed by interactive discussions. A writing committee summarized their collective findings. The Epidemiology Group found that long-term exposure to air pollution, especially metrics of traffic-related air pollution such as nitrogen dioxide and black carbon, is associated with onset of childhood asthma. However, the evidence for a causal role in adult-onset asthma or COPD remains insufficient. The Mechanistic Group concluded that air pollution exposure can cause airway remodeling, which can lead to asthma or COPD, as well as asthma-like phenotypes that worsen with long-term exposure to air pollution, especially fine particulate matter and ozone. The Clinical Group concluded that air pollution is a plausible contributor to the onset of both asthma and COPD. Available evidence indicates that long-term exposure to air pollution is a cause of childhood asthma, but the evidence for a similar determination for adult asthma or COPD remains insufficient. Further research is needed to elucidate the exact biological mechanism underlying incident childhood asthma, and the specific air pollutant that causes it.
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subjects Adult
Age Factors
Air Pollutants - analysis
Air Pollutants - toxicity
Air pollution
Air Pollution - adverse effects
Air Pollution - analysis
American Thoracic Society Documents
Asthma
Asthma - etiology
Asthma - physiopathology
Causality
Child
Chronic obstructive pulmonary disease
Environmental Exposure - adverse effects
Humans
Lung diseases
Ozone - toxicity
Particulate Matter - analysis
Pulmonary Disease, Chronic Obstructive - etiology
Pulmonary Disease, Chronic Obstructive - physiopathology
Respiratory diseases
Societies, Medical
Traffic-Related Pollution - adverse effects
United States
title Outdoor Air Pollution and New-Onset Airway Disease. An Official American Thoracic Society Workshop Report
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