Cortical Surfaces Mediate the Relationship Between Polygenic Scores for Intelligence and General Intelligence

Abstract Recent large-scale, genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with general intelligence. The cumulative influence of these loci on brain structure is unknown. We examined if cortical morphology mediates the relationship between GWAS-derived p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2020-04, Vol.30 (4), p.2708-2719
Hauptverfasser:	Lett, Tristram A, Vogel, Bob O, Ripke, Stephan, Wackerhagen, Carolin, Erk, Susanne, Awasthi, Swapnil, Trubetskoy, Vassily, Brandl, Eva J, Mohnke, Sebastian, Veer, Ilya M, Nöthen, Markus M, Rietschel, Marcella, Degenhardt, Franziska, Romanczuk-Seiferth, Nina, Witt, Stephanie H, Banaschewski, Tobias, Bokde, Arun L W, Büchel, Christian, Quinlan, Erin B, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Ittermann, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Fröhner, Juliane H, Smolka, Michael N, Whelan, Robert, Schumann, Gunter, Tost, Heike, Meyer-Lindenberg, Andreas, Heinz, Andreas, Walter, Henrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Cerebral Cortex - diagnostic imaging Cerebral Cortex - physiology Female Genome-Wide Association Study - methods Humans Intelligence - physiology Longitudinal Studies Male Multifactorial Inheritance - physiology Original
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Recent large-scale, genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with general intelligence. The cumulative influence of these loci on brain structure is unknown. We examined if cortical morphology mediates the relationship between GWAS-derived polygenic scores for intelligence (PSi) and g-factor. Using the effect sizes from one of the largest GWAS meta-analysis on general intelligence to date, PSi were calculated among 10 P value thresholds. PSi were assessed for the association with g-factor performance, cortical thickness (CT), and surface area (SA) in two large imaging-genetics samples (IMAGEN N = 1651; IntegraMooDS N = 742). PSi explained up to 5.1% of the variance of g-factor in IMAGEN (F1,1640 = 12.2–94.3; P
ISSN:	1047-3211 1460-2199 1460-2199
DOI:	10.1093/cercor/bhz270