Immunohistochemistry analysis of pulmonary infiltrates in necropsy samples of children with non-pandemic lethal respiratory infections (RSV; ADV; PIV1; PIV2; PIV3; FLU A; FLU B)

Highlights • Respiratory infections represent a globally cause of mortality in childhood. • Individuals with impaired cellular immunity have more severe diseases. • The inflammatory response appears to play role in recovery from these diseases. • TCD8+ count (immunohistochemistry) was higher in the...

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Veröffentlicht in:	Journal of clinical virology 2014-10, Vol.61 (2), p.211-215
Hauptverfasser:	de Souza Costa, Victor Horácio, Baurakiades, Emanuele, Viola Azevedo, Marina Louise, Traiano, Gabriela, Kowal Rosales, Jeana, Kunze Larsen, Kelly Susana, Raboni, Sonia Maria, de Noronha, Lucia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Adolescent Allergy and Immunology Antigens, CD - analysis Autopsy Child Childhood Humans Immunohistochemistry Infant Infectious Disease Lung - pathology Male Pneumonia Pulmonary Alveoli - pathology Respiratory Tract Infections - immunology Respiratory Tract Infections - pathology Virus Virus Diseases - immunology Virus Diseases - pathology
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Zusammenfassung:	Highlights • Respiratory infections represent a globally cause of mortality in childhood. • Individuals with impaired cellular immunity have more severe diseases. • The inflammatory response appears to play role in recovery from these diseases. • TCD8+ count (immunohistochemistry) was higher in the viral pneumonias ( p = 0.04). • Tissue TCD8+ lymphocytes play role in the viral pneumonia inflammatory response.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2014.06.026