Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes

Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes

•Acquired aplastic anemia is a T-cell–mediated autoimmune bone marrow aplasia, without a known etiologic trigger.•Clonal expansion of CD8+ effector T lymphocytes can occur following vaccination and accompany graft dysfunction or aplastic anemia relapse. [Display omitted]

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Bibliographische Detailangaben
Veröffentlicht in:Blood advances 2020-04, Vol.4 (7), p.1378-1382
Hauptverfasser: Ritz, Caitlin, Meng, Wenzhao, Stanley, Natasha L., Baroja, Miren L., Xu, Chong, Yan, Patrick, Huang, Alexander C., Hausler, Ryan, Nicholas, Peter, Fan, Jian-Meng, Lieberman, David, Carreno, Beatriz M., Luning Prak, Eline T., Olson, Timothy S., Babushok, Daria V.
Format: Artikel
Sprache:eng
Schlagworte:
Anemia, Aplastic
CD8-Positive T-Lymphocytes
Exceptional Case Report
Humans
Lymphocytes
Recurrence
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Beschreibung
Zusammenfassung:•Acquired aplastic anemia is a T-cell–mediated autoimmune bone marrow aplasia, without a known etiologic trigger.•Clonal expansion of CD8+ effector T lymphocytes can occur following vaccination and accompany graft dysfunction or aplastic anemia relapse. [Display omitted]
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2019000853