Human STAT5b mutation causes dysregulated human natural killer cell maturation and impaired lytic function

Human STAT5b mutation causes dysregulated human natural killer cell maturation and impaired lytic function

In humans, the absence of STAT5b mimics the abrogated NK cell terminal maturation observed in Stat5b −/− mice. NK cells from STAT5b patients had a decreased cytolytic function and impaired convergence of lytic granules to the microtubule-organizing center.

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Veröffentlicht in:Journal of allergy and clinical immunology 2019-10, Vol.145 (1), p.345-357.e9
Hauptverfasser: Vargas-Hernández, Alexander, Witalisz-Siepracka, Agnieszka, Prchal-Murphy, Michaela, Klein, Klara, Mahapatra, Sanjana, Al-Herz, Waleed, Mace, Emily M., Carisey, Alexandre F., Orange, Jordan S, Sexl, Veronika, Forbes, Lisa R.
Format: Artikel
Sprache:eng
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Zusammenfassung:In humans, the absence of STAT5b mimics the abrogated NK cell terminal maturation observed in Stat5b −/− mice. NK cells from STAT5b patients had a decreased cytolytic function and impaired convergence of lytic granules to the microtubule-organizing center.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2019.09.016